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In the existing research, we generated a completely new knockin (KI) transgenic mouse model where by the Pro32Pro33 isoform is expressed from the endogenous integrin β

These data show that multiple signaling pathways downstream from PAR4 activation, beyond Src, modify platelet pro33 sot attachment during the context of your Pro32Pro33 mutation.

three, concomitant with increased pSrc associations in unstimulated platelets. These variations end in altered Src and FAK phosphorylation concentrations, which arise devoid of observed activation of the ligand-binding area of α

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l of total blood in sodium citrate. The still left jugular vein was exposed to inject a coagulation Resolution made up of 100 μ

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